TACK: A Novel TArgeting Chimeras Knowledge Dataset
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3,514 PROTACs and 6,561 degradation endpoints in one standardised dataset, plus the statistical benchmark code used to evaluate degradation activity models.
Published:
3,514 PROTACs and 6,561 degradation endpoints in one standardised dataset, plus the statistical benchmark code used to evaluate degradation activity models.
Published:
Automated decomposition of a PROTAC into E3 ligand, linker and warhead, via a Transformer sequence-to-sequence model and a graph-based XGBoost model.
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An open, reproducible degradation activity model that outperforms DeepPROTACs at a fraction of the complexity, trained on a curated PROTAC-DB / PROTAC-Pedia dataset.
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Implementing the FEM algorithm from scratch in Numba and CuPy.
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A series of assignments on OpenMP, Threads, and OpenCL.
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MATLAB projects on SIFT, CNNs, image registration, and triangulation.
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Implementing sequence alignment, domain assignment, main chain tracing, and steric overlaps detection.
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A framework that co-optimises multiple LSTM models for FPGA deployment via SVD-based approximation and structured pruning, reaching 3x to 5x speedups at equal accuracy loss.